Research Consortium Neurotoxikology
Mission
A variety of clinical substances and compunds are able to damage glial and neuronal cells in the central and peripheral nervous system (PNS). Of particular clinical relevance
are toxic neuropathies, which are evoked by chemotherapies (chemotherapy induced peripheral neuropathy, CIPN) and other drug
classes. It is assumed that apart from CIPN also a significant proportion of peripheral neuropathies, currently considered as "idiopathic", are caused by toxic compounds. However, the incomplete
knowledge about their pathogenesis and the lack of diagnostic measures currently prevent proper classification and appropriate therapeutic and prevention approaches.
The German Research Consortium Neurotoxikology assembles research groups in Germany,
which are devoted to research pathogenesis and prevention of chemotherapy-associated neuropathies and
other neurotoxic disorders. The mission of the consortium is to improve research in the area of neurotoxicology. By a nationwide collaboration of leading clinical and
basic-science orientated research groups the diagnosis, prevention and treatment of neurotoxic
diseases will be optimized.
research group M. Endres Charité Berlin
research areas:
neurotoxicity in the PNS
- cell culture- and animal models of chemotherapy-induced neuropathies (CIN)
- pathomechanisms and prevention of CIN
- clinical translation
PD Dr. Wolfgang Böhmerle
Charité Universitätsmedizin Berlin
Experimentelle Neurologie - AG Endres
Charitéplatz 1, 10117 Berlin
eMail: Wolfgang.boehmerle@charite.de
http://expneuro.charite.de/en/research/research_teams/interdisciplinary_stroke_research/
neurotoxicity in the ZNS
- cell culture and animal models chemotherapy-induced cognitive impairment (PCCI)
- pathomechanisms and prevention of PCCI
- clinical trials / translation:
CICARO (chemotherapy-induced kognitive alteration in patients with ovarial cancer)
contact:
Dr. Petra Hühnchen
Charité Universitätsmedizin Berlin
Experimentelle Neurologie - AG Endres
Charitéplatz 1, 10117 Berlin
eMail: petra.huehnchen@charite.de
http://expneuro.charite.de/en/research/research_teams/interdisciplinary_stroke_research/
research group C. Geber University Mainz
research areas:
-somatosensoric characteristics of patients with chemotherapy-induced neuropathies (CIN)
-Differentiation of neuropathic and myofascic pain components of patients with CIN
Contact:
PD Dr. Christian Geber
Universitätsmedizin Mainz
Klinik und Poliklinik für Neurologie
Langenbeckstraße 1
55131 Mainz
eMail: christian.geber@unimedizin-mainz.de
research group T. Hagenacker University Essen
research areas:
experimental models of chemotherapy-induced neuropathies, particular neurotoxicity of platin-compounds
pathomechanisms and prevention of neuropathic pain
role of ion channels in inflammatory neuropathies
Contact:
Priv.-Doz. Dr. med. Tim Hagenacker
Oberarzt
Bereich Erkrankungen des peripheren Nervensystems und neuromuskuläre Störungen
Klinik für Neurologie
email: tim.hagenacker@uk-essen.de
research group H.C. Lehmann University Cologne
research areas (Ilja Bobylev, Ines Klein):
experimental models of chemotherapy induced peripheral neuropathies (paclitaxel, cisplatin, bortezomib, vincristine)
Relationship between
neuroinflammation and neurotoxicity
exercise therapy of patients with peripheral neuropathy (collaboration with F. Streckmann, Spoho Köln)
Oberarzt
Universitätsklinikum Köln