Research Consortium   Neurotoxikology




Mission

A variety of clinical substances and compunds are able to damage glial and neuronal cells in the central and peripheral nervous system (PNS). Of particular clinical relevance are toxic neuropathies, which are evoked by chemotherapies (chemotherapy induced peripheral neuropathy, CIPN) and other drug classes. It is assumed that apart from CIPN also a significant proportion of peripheral neuropathies, currently considered as "idiopathic", are caused by toxic compounds. However, the incomplete knowledge about their pathogenesis and the lack of diagnostic measures currently prevent proper classification and appropriate therapeutic and prevention approaches.


The German Research Consortium Neurotoxikology assembles research groups in Germany, which are devoted to research pathogenesis and prevention of  chemotherapy-associated neuropathies and other neurotoxic disorders. The mission of the consortium is to improve research in the area of neurotoxicology. By a nationwide collaboration of  leading clinical and basic-science orientated research groups the diagnosis, prevention and treatment of neurotoxic diseases will be optimized.


research group        M. Endres        Charité Berlin

research areas:

neurotoxicity in the PNS

- cell culture- and animal models of chemotherapy-induced neuropathies (CIN)

- pathomechanisms and prevention of CIN

- clinical translation

contact:

PD Dr. Wolfgang Böhmerle

Charité Universitätsmedizin Berlin

Experimentelle Neurologie - AG Endres

Charitéplatz 1, 10117 Berlin

eMail: Wolfgang.boehmerle@charite.de

http://expneuro.charite.de/en/research/research_teams/interdisciplinary_stroke_research/

 

neurotoxicity in the ZNS

- cell culture and animal models chemotherapy-induced cognitive impairment (PCCI)

- pathomechanisms and prevention of PCCI

- clinical trials / translation:

CICARO (chemotherapy-induced kognitive alteration in patients with ovarial cancer)

 

contact:

Dr. Petra Hühnchen

Charité Universitätsmedizin Berlin

Experimentelle Neurologie - AG Endres

Charitéplatz 1, 10117 Berlin

eMail: petra.huehnchen@charite.de

http://expneuro.charite.de/en/research/research_teams/interdisciplinary_stroke_research/

research group          C. Geber        University Mainz

research areas:

-somatosensoric characteristics of patients with chemotherapy-induced neuropathies (CIN)

-Differentiation of neuropathic and myofascic pain components of patients with CIN

 

Contact:

PD Dr. Christian Geber

Universitätsmedizin Mainz

Klinik und Poliklinik für Neurologie

Langenbeckstraße 1

55131 Mainz

eMail: christian.geber@unimedizin-mainz.de


link: http://www.unimedizin-mainz.de/neurologie/startseite/mitarbeiter/aerzte/pd-dr-med-christian-geber.html




research group         T. Hagenacker University Essen

research areas:
experimental models of chemotherapy-induced neuropathies, particular neurotoxicity of platin-compounds

 

pathomechanisms and prevention of neuropathic pain

 

role of ion channels in inflammatory neuropathies

 

 

Contact:

Priv.-Doz. Dr. med. Tim Hagenacker

Oberarzt
Bereich Erkrankungen des peripheren Nervensystems und neuromuskuläre Störungen
Klinik für Neurologie


email: tim.hagenacker@uk-essen.de

 

Link: https://www.uni-due.de/neurologie/neurolab/ag_pns.php

research group      H.C. Lehmann   University Cologne

research areas (Ilja Bobylev, Ines Klein):

 

experimental models of chemotherapy induced peripheral neuropathies (paclitaxel, cisplatin, bortezomib, vincristine)

 

Relationship between

neuroinflammation and neurotoxicity

 

exercise therapy of patients with peripheral neuropathy (collaboration with F. Streckmann, Spoho Köln)

 

Contact:
Prof. Dr. Helmar C. Lehmann
Oberarzt
Klinik und Poliklinik für Neurologie
Universitätsklinikum Köln
email: helmar.lehmann@uk-koeln.de